Oct. 29: R!L Keynote Address (virtual) and Awards Ceremony (virtual)

R!L keynote address is virtual (See MS Teams link in description below.)
When Oct 29, 2021
from 01:00 PM to 02:45 PM
Contact Name
Contact Phone 852-2647 or 502-550-3928
Attendees administrators, research faculty, staff, students, fellows, post-docs, community
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R!L Keynote Speaker

Research!Louisville 2021 Keynote Speaker

Mary Jo Turk, Ph.D., Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College

Co-director, Immunology and Cancer Immunotherapy Program, Norris-Cotton Cancer Center

Lecture title: Lymph node resident memory T responses to metastatic melanoma


While immune responses against primary tumors are critically important, T cells must also be capable of functioning at sites where cancers metastasize. Our laboratory investigated how resident memory (Trm) and circulating memory (Tcirm) CD8 T cells potentiate immunity to cancer in diverse tissue microenvironments. Based on a mouse model of immunity to melanoma with associated autoimmune vitiligo, we found that tumor-specific memory T cells form a widespread network of transcriptionally distinct subsets throughout lymphoid tissues and visceral organs. Among these, we discovered a population of Trm cells that reside durably within lymph nodes (LN), where they protect against invading melanoma cells. These LN-Trm cells adopt a transcriptional program that is distinct from Trm cells in other tissues, and which uniquely predicts survival in melanoma patients with regional LN metastases. This work reveals a novel role for Trm cells in durable immunity to cancer at crucial sites of metastasis.

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+1 502-792-9582,,120961257#   United States, Louisville

Phone Conference ID: 120 961 257#

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Awards Ceremony will be virtual: Winners of R!L 2021 scientific poster competitions will be announced via a slide presentation. Certificates will be available the following week.